
In 1965, Perahia won the Young Concert Artists International Auditions.


He played duets for piano four hands with Serkin, who later made Perahia his assistant at the Curtis Institute in Philadelphia, a position he held for over a year. During the summer, he also attended the Marlboro Music School and Festival, where he studied with musicians Rudolf Serkin, Alexander Schneider, and Pablo Casals, among others. At 17, Perahia attended Mannes College, where he studied keyboard, conducting, and composition with his teacher and mentor Mieczysław Horszowski. He said his musical interests blossomed at age 15 for reasons he can't explain, and he began to practice seriously. Perahia began studying the piano at age four, with a teacher, he said, who was "very limiting" because she made him play a single piece until it was perfect. His father moved to the United States in 1935. The family came from Thessaloniki, Greece. According to the biography on his Mozart piano sonatas CD, his first language was Judaeo-Spanish, or Ladino.

Murray Perahia was born in the Bronx borough of New York City to a family of Sephardi Jewish origin.
